Sepsis is an imbalance in the host's response to infection, resulting in life-threatening organ dysfunction. It is one of the serious complications of clinical emergencies such as burns, trauma, and shock, and is also an important cause of multiple organ dysfunction syndrome (MODS) and septic shock. The use of cecal puncture surgery mimics the clinical process of abdominal sepsis infection, causing multi bacterial infections and leading to sepsis. This model is widely used in the study of symptom manifestations, survival rate after onset, and evaluation of therapeutic effects.

Observation indicators

The arrangement of myocardial cells is loose, with banded vacuolization; Infiltration of inflammatory cells in the liver, lungs, and kidneys; Small intestine mucosal edema, bleeding, white blood cell infiltration, etc; The levels of pro-inflammatory cytokines such as IL-1 β, TNF - α, and IL-6 were significantly elevated; The expression levels of serum creatinine, urea nitrogen, PCT, etc. are upregulated.

Partial Results Display