Cystitis is a common infectious diseases of lower urinary tract in clinic, with acute and chronic clinical manifestations. The former has a sudden onset, with a burning sensation during urination and pain in the urethral area. Sometimes there is urgency and severe urinary frequency. Common among women. End stage hematuria is common, and in severe cases, there may be gross hematuria and the discharge of blood clots. The symptoms of chronic cystitis are similar to those of acute cystitis, but there is no high fever. The symptoms can last for several weeks or intermittently, causing fatigue, emaciation, discomfort or dull pain in the lower back, abdomen, and bladder perineum area. Therefore, an animal model of cystitis with similar clinical manifestations was established, which can be used for drug treatment and drug screening of urinary tract retrograde infections.

Observation indicators

Inflammatory factors such as P2X3 PGE2、EP2、TNF-α、IACM-1， Pathological examination of bladder tissue and staining and counting of mast cells with toluidine blue.

Partial experimental diagram display