Among the vascular complications of diabetes, diabetes nephropathy is the main cause of end-stage renal disease and an independent risk factor of cardiovascular disease. Currently, 20% to 50% of kidney failure patients worldwide are caused by DN

The World Health Organization predicts that by 2025, about 300 million people will suffer from diabetes, 30%~40% of whom will develop diabetes nephropathy. The establishment of a good model of diabetes nephropathy is an important part of the study of its pathogenesis and prevention. Unilateral kidney ligation can lead to compensatory hypertrophy of the opposite kidney, which is the same as the result of surgical removal. Changes in blood sugar and renal function can confirm the establishment of the model.

Observation indicators:

Random blood glucose ≥ 16.7mmol/L, 24-hour urine protein content>20 mg/L, renal pathological examination

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