In clinical hepatobiliary surgery, bile duct obstruction and cholestasis are common pathological environments. Prolonged obstruction can induce permanent liver damage and even develop into liver fibrosis and cirrhosis. The rat model of biliary obstruction constructed by ligating the common bile duct can simulate the pathological state of biliary obstruction, and the success rate of modeling is high.

Observation indicators

Serum ALT, AST, TBIL, and DBIL were significantly elevated; Upregulation of serum inflammatory cytokine levels; The liver is yellow stained and swollen, with congestion and edema. The surface of the liver lobes is rough and grayish white in color; A large number of inflammatory cells infiltrate the hepatic portal area.

Partial surgical image display